Invitrogen

Procollagen I C-Peptide Monoclonal Antibody (002-04)

View all (5) Procollagen I C-Peptide antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

BTE 002-04-02

Applications
Tested Dilution
Publications

ELISA (ELISA)

1:10,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

002-04

Immunogen

PICP purified from second trimester amniotic fluid by affinity chromatography.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.97 mg/mL

Purification

Protein A/G

Storage buffer

PBS, pH 7.4

Contains

15mM sodium azide

Storage conditions

4°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1086816

Product Specific Information

BTE 002-04-02 is specific for human native PICP from amniotic fluid. Crossreactivity to other species is not determined.

BTE 002-04-02 has been successfully used ELISA procedures.

NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL

Target Information

Collagen type I is present in soft connective tissue and bone where it represents approximately 90% of the organix matrix. Collagen type I is produced from procollagen when two teloterminal propeptides are digested from the procursor and released into the circulation. The propeptide levels can be measured in serum as indicators of collagen production. Elevated values of these propeptides in serum are found in patients with various bone metabolism defects. Procollagen type I C-terminal propeptide (PICP) has a molecular weight of approximately 100 kDa and the normal range in serum depends on age and sex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Alpha-1 type I collagen; alpha1(I) procollagen; C-terminal Collagen; collagen alpha 1 chain type I; Collagen alpha-1(I) chain; collagen alpha-1(I) chain preproprotein; collagen of skin, tendon and bone, alpha-1 chain; collagen, type I, alpha 1; PICP; pro-alpha-1 collagen type 1; Procol; Procollagen; type I proalpha 1; type I procollagen alpha 1 chain

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Gene Aliases: COL1A1; EDSC; OI1; OI2; OI3; OI4

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UniProt ID: (Human) P02452

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Entrez Gene ID: (Human) 1277

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Function(s)
extracellular matrix structural constituent protein binding identical protein binding metal ion binding platelet-derived growth factor binding
Process(es)
skeletal system development blood vessel development osteoblast differentiation intramembranous ossification endochondral ossification blood coagulation visual perception sensory perception of sound positive regulation of epithelial to mesenchymal transition negative regulation of cell-substrate adhesion protein transport platelet activation extracellular matrix organization collagen fibril organization positive regulation of cell migration collagen catabolic process response to corticosteroid response to estradiol collagen biosynthetic process protein localization to nucleus tooth mineralization response to drug response to hydrogen peroxide response to peptide hormone skin morphogenesis cellular response to fibroblast growth factor stimulus tooth eruption positive regulation of transcription, DNA-templated embryonic skeletal system development regulation of immune response leukocyte migration response to cAMP response to hyperoxia face morphogenesis bone trabecula formation cartilage development involved in endochondral bone morphogenesis protein heterotrimerization cellular response to amino acid stimulus cellular response to mechanical stimulus cellular response to retinoic acid cellular response to vitamin E cellular response to tumor necrosis factor cellular response to epidermal growth factor stimulus cellular response to transforming growth factor beta stimulus positive regulation of canonical Wnt signaling pathway cellular response to fluoride
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